Redirecting to https://www.eviemagazine.com/post/is-mrna-therapy-the-new-botox ADE is a condition in which the antibodies against a pathogen increase the ability of the pathogen to get into cells. Drugs and Lactation Database (LactMed) [Internet]. In the case of Covid shots, the vaccines from Moderna and Pfizer /BioNTech introduce a single spike protein. government site. The authors also made this point by stating, The exact regulation of LINE-1 activity in response to BNT162b2 merits further study. (p. 1123). shakira. Another aspect of protein chemistry is also important. Thank you for taking time to provide your feedback to the editors. Whether the findings of the study will occur in living organisms or if the DNA converted from the vaccines mRNA will integrate with the cells genome is unknown. Two people in their 60s who received the shot were diagnosed with Guillain-Barre syndrome, out of about 20,000 vaccine recipients who participated in Pfizers Phase 3 As long as the spike protein can be detected on cell-derived membrane vesicles, the immune system will be attacking the cells that release these vesicles, they said. They used different concentrations of the vaccine and multiple timepoints to measure: Some pointed to this paper as proof that COVID-19 vaccines alter DNA. The Swedish study also found spike proteins expressed on the surface of the liver cells that researchers say may be targeted by the immune system and possibly cause autoimmune hepatitis, as there [have] been case reports on individuals who developed autoimmune hepatitis after BNT162b2 vaccination.. The mRNA in the COVID-19 vaccines helps train the body to recognize a protein from the coronavirus to trigger an immune response. The data represent RNA levels not viral particles, so while the patient samples required equal cycles of PCR to detect RNA, we cant speak to a persons contagiousness because this study does not tell us how much whole virus was present in their nasal passages. Whether our results are true for other cell types in humans, or if they are specific to mRNA vaccines, are among many questions for further research. As such, even if DNA representing the viral RNA was integrated into the cell, no other cells with the altered DNA would be produced. Table S1 summaries the vaccines 2022 Oct 21;13:475. doi: 10.25259/SNI_377_2022. 2022 Nov;28(11):2273-2287. doi: 10.1038/s41591-022-02061-1. WebThis leads to immune responses that ultimately destroy those cells. The study authors, in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. The authors said that they chose to study liver cells as Pfizer had reported that about 18% of the vaccine accumulated in the liver in 30 minutes after mice were Lund Universitymagnus [dot] rasmussen [at] med [dot] lu [dot] se, Yang de Marinis The authors of thefirst reported caseof a healthy 35-year-old female who developed autoimmune hepatitis a week after her first dose of the Pfizer COVID-19 vaccine said that there is a possibility that spike-directed antibodies induced by vaccination may also trigger autoimmune conditions in predisposed individuals as it has been shown that severe cases of SARS-CoV-2 infection are characterized by an autoinflammatory dysregulation that contributes to tissue damage, which the viruss spike protein appears to be responsible for. This study of 218 people infected with COVID-19 compared their vaccination status, severity of illness and blood samples. We saw that there was DNA converted from the vaccine's mRNA in the host cells we studied. followers 129 videos. Anti-vaccination and ivermectin proponents have gone bananas over the new study from the Lund University Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. Indeed, about 8 percent of human DNA comes from viruses inserted into our genomes during evolution. The result might be surprising, but it is also a bit surprising that such studies do not seem to have been carried out before. YDM: About 18 percent of the vaccine accumulates in the liver just 30 minutes after the vaccine is injected in mice as reported by Pfizer in EMA assessment report, and therefore we chose to study liver cells. (in-vitro swedish study) https://lnkd.in/df6hkugy Importantly, LINE-1 has been associated with various disease-related conditions, including cancer. World Health Organization Coronavirus (COVID-19) Dashboard. You can unsubscribe at any time and we'll never share your details to third parties. Bad Bunny. For these reasons, while the changes related to LINE-1 are interesting, we cant be sure the effects would be the same in a non-cancerous cell line. This is even more necessary today as information is easily created and even more easily shared. It is a good tool when studying molecular and cellular processes, they are easy to research, and since the cell lines are easily accessible, studies often start with various cell lines. YDM: A previous study from MIT has indicated that the SARS-CoV-2 virus mRNA can be converted to DNA and integrated into the human genome. The authors said that they chose to study liver cells as Pfizer had reported that about 18% of the vaccine accumulated in the liver in 30 minutes after mice were injected. Careers. As such, consumers of information should always consider messages with a questioning attitude. Reverse transcription is when DNA is made from RNA, whereas the normal transcription process involves a portion of the DNA serving as a template to make an mRNA molecule inside the nucleus. Link to the publication in Molecular Biology: Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. However, this is not an appropriate conclusion from this paper for several reasons: Logical fallacy called hasty generalization (It is important to note in this case, that the misconception was not because of the quality of the science or the messaging of the authors, but rather because others took the findings out of context.). (In The mRNA is converted to DNA as early as six hours after exposure to the vaccine. (Infographic). Associate Professor In the case of Covid shots, the vaccines from Moderna and Pfizer ( PFE )/BioNTech introduce a single spike protein. official website and that any information you provide is encrypted See here for a complete list of exchanges and delays. Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity. National Library of Medicine Side Effects. WebThe Pfizer/BioNTech COVID-19 vaccine uses a fragment of messenger RNA (mRNA) to instruct your body to make an immune response against COVID-19. DETAILS - Pfizer Vaccine Becomes DNA in The Human Liver Cells Huh7. (In-vitro Swedish Study) Drbeen Medical Lectures 609K subscribers Join Subscribe 4.3M views Streamed 11 Our COVID-19 vaccine does not alter the DNA sequence of a human cell, a Pfizer spokesperson told The Epoch Times in an email. There is a crucial difference between mRNA and DNA. This in itself motivates the need for further studies. J. Med. Bethesda (MD): National Institute of Child Health and Human Development; 2006. Unable to load your collection due to an error, Unable to load your delegates due to an error. Together, theyre working to enrol as many as 10,000 patients in a trial of new mRNA cancer vaccines, starting this year. It only presents the body with the instructions to build immunity.. Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. 2022 The Childrens Hospital of Philadelphia. Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc. The Food and Drug Administration has flagged Guillain-Barre syndrome, a rare neurological condition, as a potential risk for Pfizers respiratory syncytial virus vaccine. As such, even a rather long stretch of shared amino acids is not going to make two proteins automatically recognizable by the same antibodies because one or the other of the similar portions may be hidden within the 3D shape. Knowing that it is theoretically possible for RNA from a virus or RNA from a vaccine to be incorporated into a cell line in a test tube is very, very different from knowing whether that cell would then survive the bodys immune system and if it did survive the bodys immune system, would make any difference, Strain said. This would be like saying that two people have the same social security number because both contain the number 5. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro. Thrombotic events have been reported as a rare side effect after ChAdox1nCOV-19 vaccination that may cause death of recipient. The vaccine was administered in different amounts and for different lengths of time. This paper is not a research study; it is, at best, a modeling study. Huh7 cells were exposed to BNT162b2, and quantitative PCR was performed on RNA extracted from the cells. doi: 10.1056/NEJMoa2034577. -, Polack F.P., Thomas S.J., Kitchin N., Absalon J., Gurtman A., Lockhart S., Perez J.L., Perez Marc G., Moreira E.D., Zerbini C., et al. MR: We understood that the study would attract attention, but we think it is self-evident that this type of research should be pursued. Disclaimer. YDM: More research is needed. Our publication is the first in vitro study on the conversion of mRNA vaccine into DNA, inside cells of human origin. This is important for two reasons; both of which were acknowledged by the authors. YDM: This study does not investigate whether the Pfizer vaccine alters our genome. The site is secure. (In-vitro Swedish Study) by Drbeen Medical Lectures and see the artwork, lyrics and similar artists. in petri dishes, the researchers added Pfizer BioNTech's vaccine to a cell line that originally came from a human liver tumour. This paper compared protein sequences from the SARS-CoV-2 virus to protein sequences in humans and described where the latter are found in the body. These insects are generally larger in temperate areas than in the tropics. For general feedback, use the public comments section below (please adhere to guidelines). Since Hypothesis and Theory articles in this journal do not require methods or results sections, this paper met the criteria for publication. Kyriakopoulos AM, Nigh G, McCullough PA, Seneff S. Cureus. Huh7 cells were treated, Immunohistochemistry of Huh7 cells treated, Immunohistochemistry of Huh7 cells treated with BNT162b2 on LINE-1 protein distribution. 2022 Feb 28;194(8):E297-E305. Published on followers 26 videos. Khehra N, Padda I, Jaferi U, Atwal H, Narain S, Parmar MS. AAPS PharmSciTech. hasty generalization and appeal to ignorance. Whether our results are true for other cell types in humans, or if they are specific to mRNA vaccines, are among many questions for further research. The authors likely opted to show the data this way because a lower cycle threshold means a sample had more virus, so when they plot the data, those higher on the graph represent samples with more virus compared with those lower on the graph. Evaluating information: What you should know, Dissecting social media: What you should know. Click here:\rhttps://www.drbeen.com/yt-special-p/\r\rWant to support this work? This is the first time that researchers have shown in vitro or inside a petri dish how an mRNA vaccine is converted into DNA on a human liver cell line, and is what health experts and fact-checkers said for over a year couldnt occur. Materials in this section are updated as new information and vaccines become available. Social media users are falsely claiming that a Swedish study conducted by Lund University found that mRNA COVID-19 vaccines permanently alter human DNA. The results have in many cases been misinterpreted, the Q&A also stated. Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver. Rasmussen also said, cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans.. doi: 10.1038/s41586-020-2639-4. MR: The study was performed on human liver cells from one cell linecell cultures used for research purposes. The authors also pointed out that this cell line has been shown to have genetic and protein expression differences specific to RNA metabolism (p. 1123). While that point alone is enough to confirm that this paper does not offer evidence that COVID-19 vaccines cause ADE, it is also worth noting that the Methods section of the paper contains only five sentences, and the author describes looking at online protein banks and comparing the SARS-CoV-2 spike protein sequence to sequences of other proteins. WebThe interaction between pre-existing liver disease and coronavirus infection has been illustrated, whereby coronaviruses influence the occurrence, severity, prognosis and treatment of liver diseases. Webpfizer vaccine becomes dna in liver cells. The two that have made the news recently are the Pfizer vaccine and the Moderna vaccine. While the Moderna vaccines are meeting this specification, the Pfizer vaccines are 10 fold higher in contamination with 1 DNA molecule per 350 mRNAs. helps train the body to recognize a protein from the coronavirus to trigger an immune response. The study, conducted by researchers at Lund University in Sweden and published in a peer-reviewed journal, investigated the effect of Pfizers mRNA COVID-19 vaccine on a human cell line that was derived from liver cancer tissue. A new Swedish study published in MDPIfound that the Pfizer vaccine goes into liver cells and converts to DNA, challenging claims so far that the mRNA COVID-19 vaccines do not change or interact with your DNA in any way. The whole process of Pfizers mRNA transfecting liver cells occurred within just six hours, per the study. A gene that the researchers studied produces the protein LINE-1. This three-part series was aimed at describing several important aspects of science. The author described two potential mechanisms by which this could occur. Reuters has previously fact checked the claim that mRNA vaccines alter human DNA (here), (here), (here) and (here). Neither your address nor the recipient's address will be used for any other purpose. The https:// ensures that you are connecting to the We show that the vaccine enters liver cells as early as six hours after the vaccine has been administered. Microbiol Spectr. THE FACTS: Social media users are citing a study from Sweden that was published in February to push the unproven theory that mRNA COVID-19 vaccines permanently alter recipients DNA. Lund University Further studies are needed to demonstrate the effect of BNT162b2 on genomic integrity, including whole genome sequencing of cells exposed to BNT162b2, as well as tissues from human subjects who received BNT162b2 vaccination, the authors said. The result might be surprising, but it is also a bit surprising that such studies do not seem to have been carried out before. With this information, the author suggested that the quantity of overlap in some sequences could cause the immune system to attack ones own proteins, called autoimmunity, leading to more severe disease. shakira. 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