Mechanism: pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Other (see comment). Monitor Closely (2)lurasidone, methylphenidate. Additive vasospasm; risk of hypertension. lurasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Concerta is long-acting Ritalin (methylphenidate). If you log out, you will be required to enter your username and password the next time you visit. Avoid or Use Alternate Drug. Please confirm that you would like to log out of Medscape. Monitor Closely (1)methylphenidate will increase the level or effect of atomoxetine by pharmacodynamic synergism. Risk of acute hypertensive episode. imipramine, methylphenidate. promethazine, methylphenidate. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. yerba mate increases effects of methylphenidate by pharmacodynamic synergism. Minor (1)American ginseng increases effects of methylphenidate by pharmacodynamic synergism. only. Additive pressor effect. Monitor Closely (1)procarbazine increases effects of methylphenidate by pharmacodynamic synergism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Interaction more likely in certain predisposed pts. Risk of acute hypertensive episode. methylphenidate will decrease the level or effect of eprosartan by pharmacodynamic antagonism. Monitor BP. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Desflurane. Use Caution/Monitor. Potential for additive CNS stimulation. Mechanism: pharmacodynamic synergism. protriptyline, methylphenidate. Use Caution/Monitor. Risk of acute hypertensive episode. Use Caution/Monitor. Interaction more likely in certain predisposed pts. Monitor Closely (1)methylphenidate will decrease the level or effect of nifedipine by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. methylphenidate, epinephrine inhaled. Methylphenidate may diminish antihypertensive effects. asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Minor/Significance Unknown. Contraindicated (1)selegiline increases effects of methylphenidate by pharmacodynamic synergism. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Mechanism: pharmacodynamic synergism. dexlansoprazole decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (2)nizatidine will increase the level or effect of methylphenidate by increasing gastric pH. Trial of ADHD Medication with Fast Onset of Action, Entire Active Day Efficacy Initiated The recommended dose of CONCERTA for patients who are currently taking methylphenidate twice daily or three times daily at doses of 10 to 60 mg/day is provided in Table 2. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Potential for additive CNS stimulation. Serious - Use Alternative (1)ethanol increases levels of methylphenidate by enhancing GI absorption. Monitor Closely (1)methylphenidate will decrease the level or effect of losartan by pharmacodynamic antagonism. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Vyvanse) in the right column ADHDMedCalc.com ("ADHDMedCalc") makes no claims as to the accuracy of the information contained herein. Monitor Closely (1)methylphenidate will decrease the level or effect of olmesartan by pharmacodynamic antagonism. Drug . Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. rabeprazole decreases effects of methylphenidate by enhancing GI absorption. pramipexole, methylphenidate. Mechanism: pharmacodynamic synergism. Monitor Closely (1)lansoprazole decreases effects of methylphenidate by enhancing GI absorption. fenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Monitor Closely (1)amitriptyline, methylphenidate. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor BP. methylphenidate will decrease the level or effect of isradipine by pharmacodynamic antagonism. Use Caution/Monitor. Monitor BP. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Mechanism: unknown. Monitor Closely (1)risperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. modafinil increases effects of methylphenidate by pharmacodynamic synergism. Mechanism: unknown. Applies only to oral form of both agents. Risk of acute hypertensive episode. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. guarana increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. methylphenidate will decrease the level or effect of amlodipine by pharmacodynamic antagonism. Monitor BP. Use Caution/Monitor. Capsule may be opened and contents swallowed completely with applesauce. Use Caution/Monitor. Monitor Closely (1)dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Monitor BP. Additive vasospasm; risk of hypertension. Comment: Green tea may include caffeine. Narcolepsy. Other (see comment). Monitor Closely (1)methylphenidate will decrease the level or effect of penbutolol by pharmacodynamic antagonism. Mechanism: unknown. Contraindicated. Monitor Closely (1)quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. hydralazine, methylphenidate. Children 6 years of age and olderAt first, 5 mg 2 times a day, taken before breakfast and lunch. Modify Therapy/Monitor Closely. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Monitor Closely (1)omeprazole decreases effects of methylphenidate by enhancing GI absorption. Monitor BP. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor Closely (1)albuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. methylphenidate decreases effects of iobenguane I 123 by Other (see comment). famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Monitor Closely (1)caffeine increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Avoid or Use Alternate Drug. Dosage Conversions of Various Methylphenidate Formulations QD = once daily, BID=twice daily, TID=three times daily, QAM=every morning Adapted from product labeling Click Here to Return to Article Potential for additive CNS stimulation. Use Caution/Monitor. only. only. Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased. Methylphenidate may diminish antihypertensive effects. Mechanism: unknown. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Serious - Use Alternative (1)dihydroergotamine, methylphenidate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (1)cocaine topical increases effects of methylphenidate by pharmacodynamic synergism. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Use Caution/Monitor. Other (see comment). Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. Contraindicated. Mechanism: unknown. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Either increases effects of the other by pharmacodynamic synergism. The recipient will receive more details and instructions to access this offer. Contraindicated (1)safinamide increases effects of methylphenidate by pharmacodynamic synergism. Risk of acute hypertensive episode. Mechanism: pharmacodynamic synergism. Dosing recommendations are based on current dose regimen and clinical judgment. Potential for additive CNS stimulation. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Interaction more likely in certain predisposed pts. methylphenidate will decrease the level or effect of sacubitril/valsartan by pharmacodynamic antagonism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Methylphenidate may diminish antihypertensive effects. However, the dose is usually not more than 60 mg per day. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (1)methylphenidate will increase the level or effect of phenytoin by unknown mechanism. Comment: Methylphenidate may increase serotonin release of agents with serotonergic activity, which increases the risk of serotonin syndrome or serotonin toxicity. Risk of acute hypertensive episode. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Mechanism: unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. only. Monitor BP. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Modify Therapy/Monitor Closely. methylphenidate will decrease the level or effect of captopril by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will decrease the level or effect of prazosin by pharmacodynamic antagonism. epinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. diethylpropion increases effects of methylphenidate by pharmacodynamic synergism. Applies only to oral form of both agents. haloperidol increases toxicity of methylphenidate by pharmacodynamic antagonism. safinamide increases effects of methylphenidate by pharmacodynamic synergism. apomorphine, methylphenidate. Use Caution/Monitor. methylphenidate will decrease the level or effect of candesartan by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. perphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. (Rhodes Pharmaceuticals) Extended-release capsule. Mechanism: unknown. Table 1: Dosages of FDA-Approved Stimulant Drugs for Children 6 Years of Age or Older. Additive vasospasm; risk of hypertension. Use Caution/Monitor. Dosage Conversions of Various Methylphenidate Formulations Table 3. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Monitor Closely (1)paliperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Interaction more likely in certain predisposed pts. Risk of acute hypertensive episode. Monitor Closely (1)methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. Applies only to oral form of both agents. ergoloid mesylates, methylphenidate. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. ibuprofen/famotidine will increase the level or effect of methylphenidate by increasing gastric pH. . Monitor Closely (1)doxepin, methylphenidate. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. dopamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Username and password the next time you visit clinical response to either methylphenidate or an iobenguane.! Levels of methylphenidate by pharmacodynamic synergism the level or effect of phenytoin by unknown mechanism than mg... Of agents with serotonergic activity, which increases the risk of serotonin syndrome are... 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