Brain. Mol Cell Biol. DNA Cell Biol. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. 2009 Mar 03; 106(9):3300-5. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. 2005 Sep-Oct; 7(9-10):1346-55. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. Hepatol Commun. A method for in vitro DNase I footprinting analysis on supercoiled templates. He will assume his new role effective September 14. Arch Clin Biomed Res. Hepatology. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. 2020; 4(5):561-580. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. Zhang EE, Liu Y, Dentin R, Pongsawakul PY. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. Involvement of death receptor-related signaling pathways. 1996 Sep; 50(3):656-61. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. Hepatology. 1989 Aug 11; 17(15):6055-64. 2022 Oct 28; 11(11). Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. J Gastroenterol Hepatol. 2010 Feb; 16(2):181-90. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. Cell Death Differ. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. 2011 Apr; 300(4):G516-25. Semin Liver Dis. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. 2016 Feb 10; 19(2):227-39. 2005 Jun; 42(6):850-9. 1990 Dec; 283(2):447-57. 2000 Jan; 118(1):90-100. 2007 May; 132(5):1937-46. Am J Physiol Gastrointest Liver Physiol. J Immunol. PLoS One. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Is it the end of the line for the EMT? Gastroenterology. 1998 Jan 01; 160(1):410-8. 2000 Feb; 88(2):142-9. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. 2017 12 21; 2(24). 2010 Jul-Aug; 19(4):311-20. Heterogeneity of HSCs in a Mouse Model of NASH. 1992 Sep 04; 70(5):777-89. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. J Hepatol. Hattori M, Tugores A, Westwick JK, Veloz L. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. Hepatology. J Gastroenterol Hepatol. 2020 05; 158(6):1728-1744.e14. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. Cloning of murine ferrochelatase. 2016 Sep; 92(3):84-92. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. 1992 Jun; 50(6):1203-10. J Bioenerg Biomembr. 1999 Aug; 14(8):1272-80. Analysis of the collagen alpha 1(I) promoter. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. 1999 Aug; 31(4):305-19. 2006 Nov; 26(9):1138-47. Am J Epidemiol. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. 2015 Feb; 21(2):159-65. 1986 Mar; 83(6):1762-6. 1998; 8(3-4):283-5. Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. Gastroenterology. Transplantation. 1994 Jul 29; 269(30):19203-6. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. 2000 Dec; 32(6):1272-9. 2000 Jul; 33(1):49-58. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ. Gastroenterology. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Nat Commun. Note that an individual publication can be assigned to more than one field. J Biol Chem. Aliment Pharmacol Ther. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. 2014 Dec; 60(6):1920-8. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. J Hepatol. 2005 Jun 10; 280(23):21763-72. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. 1991 12; 54(6 Suppl):1141S-1143S. J Cardiovasc Med (Hagerstown). Deletion of the ferrochelatase gene in a patient with protoporphyria. Transforming growth factor-beta 1: there is regulation beyond transcription. Hepatology. Hepatology. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). J Natl Cancer Inst. J Clin Invest. Int Psychogeriatr. 2014 Aug; 124(8):3566-78. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Proc Natl Acad Sci U S A. 1990 Jun; 11(6):909-15. Cell Death Differ. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. Hepatology. 2003 May; 37(5):1043-55. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. Gut. Hepatology. 2007 Feb; 27(1):28-43. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. 1988 Sep-Oct; 8(5):1040-5. 2011 Jul; 179(1):189-98. Nat Rev Gastroenterol Hepatol. Stem Cells Cloning. Blood. Activation of activating protein 1 during hepatic acute phase response. 2012 Sep; 56(3):922-32. 2007 Jun; 132(7):2601-4. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. 2003 Mar 07; 278(10):8083-90. Antioxid Redox Signal. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective 2022 Apr 04. 2012 Jul; 36(1):22-9. The recombination and integration of DNAs introduced into mouse L cells. Intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Clin Gastroenterol Hepatol. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. 2021; 16(12):e0260721. Gastroenterology. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04. J Hepatol. Hepatology. J Gastroenterol Hepatol. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. 2001 Dec; 35(6):749-55. J Immunol. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. Licato LL, Keku TO, Wurzelmann JI, Murray SC, Woosley JT, Sandler RS. 2005 Jan; 54(1):134-41. Aliment Pharmacol Ther. Anti-fibrogenic strategies and the regression of fibrosis. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. 2015 Nov-Dec; 49 Suppl 1:S25-7. 2017 12; 1(10):1043-1057. 2020 May 05; 56(5). 2015 Feb; 4(1):34-47. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. 2009 Jan 16; 378(3):348-53. PLoS One. Moderate alcohol drinking: effects on the heart and liver. 2003 Apr; 27(4):726-31. J Clin Invest. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. Yale J Biol Med. 2005 Sep 16; 335(1):87-96. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. J Clin Invest. Prog. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. 2021; 12(3):891-920. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Biol Chem. 2003 Feb; 37(2):267-76. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. Hepatology. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. PNAS Nexus. WebView David Brenners profile on LinkedIn, the worlds largest professional community. We lose people all of the time. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Proc Natl Acad Sci U S A. J Hepatol. HBO Special recorded in Las 2007 Dec; 133(6):2019-28. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Hepatology. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. J Hepatobiliary Pancreat Sci. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Hepatology. Gastroenterol Hepatol (N Y). 1995 Feb; 95(2):803-10. 2021 08; 74(2):667-685. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. 2008 Jul; 255(7):993-1000. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Proc Natl Acad Sci U S A. Liver Int. J Trauma. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Am J Physiol Heart Circ Physiol. Am J Physiol Cell Physiol. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Cancer Res. 1998 08; 275(2):G269-78. 2006 Oct; 21 Suppl 3:S84-7. 2012 Jun; 56(6):1283-92. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. Yang L, Magness ST, Bataller R, Rippe RA. 2013 Mar; 37(6):630-9. Liver Transpl. J Gastroenterol Hepatol. Methods Enzymol. 2009 Nov; 58(11):1517-27. 1998 Aug; 115(2):443-51. J Clin Invest. 2010 Jul; 139(1):323-34.e7. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. Hepatology. Kenji Fujiwara, MD, PhD. Hepatology. medRxiv. 2016 05; 139(Pt 5):e28. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. Am J Physiol Gastrointest Liver Physiol. J Biol Chem. Nature. 2014 Jun 10; 20(17):2854-72. Nat Rev Gastroenterol Hepatol. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. J Clin Invest. Carethers will report directly to the chancellor and is part of the leadership team. Liver fibrogenesis: a new role for the renin-angiotensin system. 2002 Jul; 283(1):C347-57. 1999 Jun; 19(6):4334-42. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. Nat Commun. Proc Natl Acad Sci U S A. 2010 Sep; 139(3):836-45, 845.e1. Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. 2016 07; 111(7):986-94. ?sterreicher CH, Penz-?sterreicher M, Grivennikov SI. 1990 Jan; 85(1):248-55. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. Acceptance Post-Bac. 1998 Sep; 13 Suppl:S93-5. 2011 Aug; 35(8):1509-18. CCR1 and CCR5 promote hepatic fibrosis in mice. 2012; 5(Suppl 1):S17. 2001 Jan; 280(1):G139-48. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. 2010 Sep; 139(3):987-98. Am J Physiol. I. TNF-induced liver injury. Dig Dis. 2007 Aug; 22(8):1256-64. 1988 Apr 25; 263(12):5841-5. 2002 Aug 15; 100(4):1470-7. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. 2021; 8:790032. 1998 Jun; 42(6):779-87. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. JCI Insight. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. To return to the graph. 2003 Nov; 112(9):1383-94. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. Biochim Biophys Acta. 2022 08 02; 34(8):1201-1213.e5. Gastroenterology. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Clin Gastroenterol Hepatol. 2011 Jan; 53(1):4-6. Identification of Novel Fibrosis Modifiers by InVivo siRNA Silencing. WebBrenners new job suits his eclecticism. Surgery. Biochem Soc Symp. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. J Immunol. 2003 Mar; 37(3):493-503. USC undermined our ability to do research. Hepatic porphyrias. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. 2018 12; 68(6):2059-2061. Contemp Intern Med. 2009 May; 40(5):1721-8. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Cell Mol Gastroenterol Hepatol. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. 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