It is false to claim that Pfizer's biodistribution study showed lipid nanoparticles accumulating in the highest concentration in the ovaries. Stem Cells Transl Med. Copyright 2023 Pandemic Timeline. Its very disconcerting We have known for a long time that the spike protein is a pathogenic protein. Its very disconcerting. The bottom line is mRNA Covid vaccines are still considered experimental by the FDA as research continues to be done. The biodistribution study obtained by Bridle showed lipid nanoparticles from the vaccine did not stay in the deltoid muscle where they were injected as the vaccine's developers claimed would happen, but circulated throughout the body and accumulated in large concentrations in organs and tissues, including the spleen, bone marrow, liver, adrenal 8.7. Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizer's biodistribution study from the Japanese regulatory agency. You can view The Poynter Institutes most-recent public financial disclosure form 990, Poynter ACES Introductory Certificate in Editing. Did Pfizer Fail to Perform Industry Standard Animal Testing Prior to Initiation of MRNA Clinical Trials? See the post about the approval for details. Guidelines on ensuring the quality and safety of pharmaceuticals and medical devices derived from the processing of autologous human somatic stem cells. Information on the biodistribution (BD) of cell therapy products (CTPs) is essential for prediction and assessment of their efficacy and toxicity profiles in non-clinical and clinical studies. (11 subjects out of 13 had S-protein in blood. Since spike proteins cause the coronavirus infection, they are the catalyst used in COVID-19 vaccines. The data from this study is not yet available in the public domain but this might provide evidence of vaccine delivery in the brain. DO NOT forget Japanese biodistribution study looking at lipid nano-particles in rats & how they bio-accumulated in first 48 hours post administration; understand that this links direct to COVID jabs Dr. Byram Bridle was attacked for his work showing that content of the COVID VACCINE did not stay in the injection site (arm) but leeched into the . Production and hosting by Elsevier B.V. All authors declare that they have no competing interests. Now, we have clear-cut evidence that the vaccines that make the cells in our deltoid muscles manufacture this protein, [we now know] the vaccine itself plus the protein gets into blood circulation. Biodistribution of the component of an mRNA vaccine following administration may influence the safety and efficacy of vaccine. At first glance, this information seems relatively straightforward. Image . The European Medicine Agency (EMA) is an agency of the European Union (EU) in charge of the Evaluation and Supervison of Medicinal Products. The attack causes damage to the lining, which results in inflammation. People will continue to gather evidence supporting the vaccine, and people will continue to gather evidence against the vaccine. Vaccine Researcher Admits Big Mistake, Says Spike Protein Is Dangerous Toxin.. Read our disclaimer for details. Please read and agree to the disclaimer before watching this video.. SARS-COV-2 Spikes in Ovaries from Pfizer-BioNTech Vaccine?There has been some uncertaint. Unable to load your collection due to an error, Unable to load your delegates due to an error. Biomedicines. Over 48 hours, distribution was mainly observed to liver, adrenal glands, spleen and ovaries. My intent is to bring you facts, not conjecture or opinion. https://www.ema.europa.eu/en/documents/assessment-report/comirnaty-epar-public-assessment-report_en.pdf. Luciferase signals at the injection sites, most likely reflecting distribution to the lymph nodes draining the injection sites, peaked 6h post injection with signals of approximately 10 000 times of buffer control animals. Pingback: 13th June MUST SEE VIDEOS & DOCUMENTS: Based Amy. You can view The Poynter Institutes most-recent public financial disclosure form 990, Poynter ACES Introductory Certificate in Editing. Additionally, according to Bridle, an alarming study not yet accepted for publication that initially attempted to verify that antibodies from the vaccine get transferred through breast milk (suggesting some protection for babies), instead inadvertently discovered the mRNA vaccine spike proteins are transferred through the breast milk, thus passing the COVID-19 vaccine vector itself into breastfeeding infants. doi: 10.1371/journal.pone.0135389. Theranostics. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). In a recent interview1 with Alex Pierson (above), Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., dropped a shocking truth bomb that immediately went viral, despite being censored by Google. 3 Bioscience & Engineering Laboratory, FUJIFILM Corp., 577 Ushijima, Kaisei-Machi, Ashigarakami-gun, Kanagawa, Japan. 12 . This is a problem, because rather than instructing your muscle cells to produce the spike protein (the antigen that triggers antibody production), spike protein is actually being produced inside your blood vessel walls and various organs, where it can do a great deal of damage. Trends of cell quantification using Alu-qPCR methods. Apart from its role in energy production, mitochondria are crucial for innate immunity, reactive oxygen species (ROS) generation, and apoptosis; all of these are important in COVID-19 pathogenesis. Number of biodistribution (BD) studies in cell-based therapeutic product as of September 2018 in comparison among (a) local or systemic administration product, (b) commercialized or product in clinical phases, (c) biodistribution measurement modalities, (d) clinical phases of development, (e) used animal species and (f) measurement modalities and biodistribution study duration (refer to Supplementary Table1). Next, LPP formulated with mRNA encoding luciferase as a model. Thrombocytopenia is a commonly-reported side effect of COVID-19 vaccines, as are blood clots, strokes and lethal heart attacks all of which are pointing toward spike proteins causing vascular damage. Click to access 672212000_30300AMX00231_I100_1.pdf, Pingback: Vaccine Shedding: The Harm For Those Who Choose NOT To Be Vaccinated The Courtenay Turner Podcast. In summary, normally, the spike protein on a virus will collapse on itself and fall into the cell once it attaches to the ACE2 receptor. It only looked at where the lipid nanoparticles go. 2020 Jun 1;18:176-188. doi: 10.1016/j.omtm.2020.05.029. (a) Number of cell-based therapeutic product in cell formulation and number of cell-based therapeutic product with or without biodistribution study in (b) cell-suspension CTP and (c) tissue or cell-sheet CTP (refer to Supplementary Table1). in Japan for DNA vaccines and recombinant virus vaccines, or prior to the initiation of a large-scale clinical trial in Japan for LNP-mRNA vaccines. We thought the spike protein was a great target antigen; we never knew it was a toxin. In her paper, Worse Than The Disease: Reviewing Some Possible Unintended Consequences of mRNA Vaccines Against COVID-19, published in the International Journal of Vaccine Theory, Practice and Research in collaboration with Dr. Greg Nigh,16 Seneff explains why the unnatural spike protein is so problematic. For an LNP-mRNA vaccine, DNA vaccine, or recombinant virus vaccine, a biodistribution study with the SARS-CoV-2 vaccine candidate is generally needed. Adams AJ, LaBonte JP, Ball ML, Richards-Hrdlicka KL, Toothman MH, Briggs CJ. The Japanese biodistribution study of Pfizer's mRNA vaccine has also found that 0.02% and 0.009% of the vaccine administered dose ended up in the brain at 2-hour and 48-hour, respectively: Multifunctional NP-based technologies with diagnostic and therapeutic functions are being developed for in vivo applications. (a) DNA extraction, (b) PCR detection, (c) units, and (d) primer and probe sequences (refer to Supplementary Table3). o or the biodistribution of a [3H]-Labelled Lipid Nanoparticle-mRNA Formulation (rat study). The objective of this guideline is to provide harmonised recommendations for the conduct of nonclinical biodistribution (BD) studies in the development of gene therapy (GT) products. Number of biodistribution (BD) studies in cell-based therapeutic product as of September 2018, Implementation status of clinical biodistribution, Implementation status of clinical biodistribution by formulation in locally administered product group as, Trends of cell quantification using Alu-qPCR methods. Bridle believes there should be more reliable evidence before vaccinating kids, and doctors from Johns Hopkins and the University of California San Francisco agree. Bridle emphasized that the spike protein could cross the blood-brain barrier, causing neurological damage, explaining why fatal blood clots are often seen in the brain. For example, in the development of new compounds for PET ( positron emission tomography) scanning, a radioactive isotope is chemically joined with a peptide (subunit of a protein ). 8.8. Remember to check the date when the fact-check you are reading was published before sharing it. What is the real truth? In line with this, results from the newly transmitted study 185350 indicate a broader biodistribution pattern." The "Japanese biodistribution study," referenced in the online article appears to be a Japanese translation of a Pfizer toxicology and biodistribution study, which shows nothing like what is being claimed. Technically, it is not following the mRNA vaccine itself but following where the LNP container-luciferine goes as a surrogate to understanding where the mRNA may go. When a substance is injected into the body, tracking where it goes- its biodistribution is important to know. The study has been supported financially by the Japan Agency for Medical Research and Development and Kitasato Institute. Dr Joseph Mercola Story at-a-glance Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizer's biodistribution study from the Japanese regulatory agency. Is there a difference between the spike protein in the virus itself and the spike protein in the vaccines in terms of effects on the body described here? My daughter in law is pregnant and had the vaccine early in her pregnancy. Please Donate to this site so that we can continue to bring you important updates concerning the Covid Virus Pandemic. As questions intensify surrounding the true origins of SARS-CoV-2, the devastating discovery that spike proteins reach the bloodstream leaves wide open the door for many other legitimate questions about the long-term safety of COVID-19 vaccinesfor example, with it accumulating in the ovaries, will we be rendering some young people infertile?Bridle concluded: We made a big mistake; we didnt realize it until now. In biodistribution study, two groups of SD rats (15 rats/sex/group) were injected intramuscularly with AdC68-19S 2 10 11 vp (twofold the proposed clinical dose of 1 10 11 vp/dose) or vehicle, respectively, on day 1. The pandemic and its consequences are constantly evolving and data that was accurate weeks or even days ago might have changed. When the spike protein interacts with the ACE2 receptor, it can disrupt mitochondrial signaling, thereby inducing the production of reactive oxygen species and oxidative stress. Japan has administered COVID-19 vaccine doses to more than 10 million people, the Prime Minister's Office said Wednesday, as the country tries to speed up inoculations that are lagging far behind other developed countries. As The Defender reported June 3, Bridle received a copy of a Japanese biodistribution study which had been kept from the public as a result of a freedom of information request made to the Japanese government for Pfizer data. The study started last September 16, 2020 and the planned end date is March 31, 2022. Its the first time ever scientists have been privy to seeing where these messenger RNA [mRNA] vaccines go after vaccination, Bridle told Pierson.10. In response to information not being available on the internet, a Citizen petition to the FDA was filed by 27 prominent health experts and scientists on June 1, 2021, requesting proper pharmacokinetic and biodistribution safety studies be revealed or conducted by the vaccine manufacturers. We thought the spike protein was a great target antigen. The #CoronavirusFacts database records fact-checks published since the beginning of the COVID-19 outbreak. I live in Japan. In the biodistribution study, luciferase RNA-encapsulated LNP was administered intramuscularly to BALB/c mice, and the expression of luciferase was observed at the site of administration, and also in the liver, although at a lower level. Biodistribution; Cell therapy product; Imaging; MRI; PET; SPECT; qPCR. 2011 Oct;17(10):881-90. doi: 10.1089/acm.2010.0481. Vitamin D Part I: Is Vitamin D really a vitamin? For Vaxzevria, a single-dose intramuscular biodistribution study with AZD1222 in mice (study 514559) was submitted post-authorisation. 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Brindle, who stated the importance of sharing this new information openly, recently visited On Point with Alex Pierson and spoke at length on the scary situation facing humanity as the push to vaccinate the global population against SARS-CoV-2 gains momentum. We never knew the spike protein itself was a toxin and was a pathogenic protein. Why are these questions surfacing now? I wanted links for my wife who is Japanese and could not understand my resistance to them. The author, Pankaj Prasun, points out that the virus impact on mitochondria helps explain why COVID-19 is so much deadlier for older people, the obese, and those with diabetes, high blood pressure and heart disease. Specific alterations make it far more toxic than that found on the virus itself. That, of course, is the type that's produced in a living cell by reading off a given stretch of DNA and assembling the matching RNA, after which it goes off on its own to be fed into a ribosome which will assemble proteins based on its code, reading off by three "codon" letters at a time. . This conclusion was reached by Israeli scientists, who conducted a study that showed that there is no difference in ovarian function between vaccinated and unvaccinated women. Thus, the absence of safety pharmacology studies is endorsed by the CHMP, Committee for Medicinal Products for Human Use. Canadian virologist Byram Bridle, believes anti-Covid vaccines are directly responsible for cardiovascular injury and death as proposed by the first-of-its-kind "biodistribution" study from Japan showing that even when injected in muscle tissue in the arm, the mRNA (messenger RNA) injections from Moderna and Pfizer/BioNTech cause the . ), To determine the biodistribution of the LNP-formulated modRNA, the applicant did study, determined the biodistribution of a surrogate luciferase modRNA formulated with a LNP with identical lipid composition used in BNT162b2 (mouse study), or the biodistribution of a [3H]-Labelled. There are many different types of vasculitis, including Kawasakis disease, antiphospholipid syndrome, rheumatoid arthritis, scleroderma and Sjogrens disease. Study Design Go to Resource links provided by the National Library of Medicine MedlinePlus Genetics related topics: Alzheimer disease In Japan, 10 fatal cases (five men and women) have been reported to date. It can cause damage in our body if it gets into circulation The spike protein on its own is almost entirely responsible for the damage to the cardiovascular system, if it gets into circulation.. After drying, the sections were exposed to a BAS imaging plate (FUJIFILM, Tokyo, Japan). Although no regulatory authority has recognized ICH as an adverse event associated with tozinameran (BNT162b2, Pfizer-BioNTech), fatal and non-fatal cases have been reported. He explained that, through cutting edge, peer-reviewed science, weve learned more about the many problems associated with spike proteins and COVID-19 vaccines: The SARS-CoV-2 has aspike protein on its surface. Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D. Bethesda, MD 20894, Web Policies This not only leads to impaired MAVS [mitochondrial antiviral signaling] response but also aggravates inflammation and cell death.. It is certainly understandable why the vaccine was rushed into use as an experimental product under emergency use authority, but these new findings suggest that routine quality testing issues were overlooked in the rush to authorize use. https://www.ema.europa.eu/en/documents/assessment-report/comirnaty-epar-public-assessment-report_en.pdf, *https://www.bmj.com/content/373/bmj.n958/rr-1, https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mrna.html, History of Discovery of Vitamin D, Use of Vitamin D in Chronic Disease, Origins of Vitamin D Toxicity. Thus, there is accumulation of damaged and dysfunctional mitochondria. Any objections based on the experimental status of this vaccine are now moot. Accessibility The signals from the liver region peaked 6h post injection and decreased to background levels 48h after injection. High Mutational Heterogeneity, and New Mutations in the Human Coagulation Factor V Gene. The biodistribution of hybrid nanostructures is a major subject of current nanomedical research. What is the clinical outcome? For the first time ever, the Japanese Regulatory Agency recently gave Bridle and several international collaborators access to a study called the Bio-Distribution Study. The groundbreaking research presents scientists with a more reliable understanding of where COVID-19 messenger RNA (mRNA) vaccines travel in the body after being injected. https://www.regulations.gov/docket/FDA-2021-P-0521/document. The study 514559 was aimed to examine the biodistribution of ChAdOx1 nCoV-19 in bone marrow, brain, spinal cord, sciatic nerve, and other body tissues. In vivo luciferase expression was detected at different timepoints at the injection sites and in the liver region indicating drainage to the liver. 2009 Aug;(144):3-79. Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical properties of the active pharmaceutical ingredient encapsulated. The biodistribution study of [89 Zr]Zr-DFO-TST001 demonstrated favorable pharmacokinetics with a relatively long half-life in vivo (Fig. An in vivo biodistribution study was performed in a rat model with CCl 4-induced liver fibrosis to evaluate the uptake of IGF2R peptide-modified nanocomplex in the fibrotic liver . Playing Hardball in Government and Politics, Nuclear War At the Abyss of Mass Extermination, Pfizer Bio-Distribution Study Submitted to the Japanese Government, Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizers biodistribution study from the Japanese regulatory agency. New Peer Reviewed Study on COVID-19 Vaccines Suggests Why Heart Inflammation, Blood Clots and Other Dangerous Side Effects Occur. According to this study, there was no difference in ovarian function between those who were infected with the Covid-19 and those who were not. Angiotensin II through binding to its type 1 receptors exerts pro-inflammatory, vasoconstrictive, and prothrombotic effects, while angiotensin (17) has opposing effects In addition, angiotensin II increases cytoplasmic and mitochondrial ROS generation leading to oxidative stress. He said the study shows how the. Shockingly, according to Bridle, the COVID-19 vaccine is different from traditional vaccines. Standard studies designed to assess these risks were not performed in compliance with accepted empirical research standards. But, as you can see below, unlike Bridle, Politifact neglected to go beyond interviewing someone with such a huge stake in the vaccines success. Please send me all info on any new updates. Youll also want to make sure your vitamin D level is optimized to between 60 ng/mL and 80 ng/mL (100 nmol/L to 150 nmol/L), ideally through sensible sun exposure. Dr. Bret Weinstein, Dr. Robert Malone, Steve Kirsch National Library of Medicine In study PF-07302048_06 Jul 20_072424, the applicant has used a qualified LC-MS/MS method to support quantitation of the two novel LNP exipients. Japanese government and Pfizer biodistribution study shows 75% of mRNA travels from injection site into blood and distributed into organs and across brain-blood barrier Trying to post again as original post was removed by automod for unknown reasons. Documents obtained from Japanese regulatory agency reveal that Pfizer biodistribution studies showed that mRNA and spike proteins circulate widely throughout the body. The designers of the COVID-19 vaccines expected the contents of a jab to remain in the muscular tissue where they were injected, usually an arm. This assumption was wrong. A study document obtained from the Japanese regulatory agency shows that the vaccine contents enter the bloodstream and travel to the various organs.Lab animals injected with purified spike protein into their bloodstream developed cardiovascular problems, and the spike protein was also demonstrated to cross the blood brain barrier and cause damage to the brain. So, by vaccinating people we are inadvertently inoculating them with a toxin.. Support responsible news and fact-based information today! The EIN for the organization is 59-1630423. Scientists discovered the SARS-CoV-2 spike protein circulating in the blood of eleven of the thirteen healthcare workers. We thought the spike protein was a great target antigen; we never knew the spike protein itself was a toxin and was a pathogenic protein. The https:// ensures that you are connecting to the Your body for some reason starts to attack the lining of your blood vessels, thereby causing damage and inflammation The why can differ from one case to another, but in all cases, your immune system identifies something foreign in the lining of the blood vessel, causing it to attack. Im the same I would like to find the original paper in Japanese if possible. Support responsible news and fact-based information today! Blood clots are a common result, and can occur either because the platelets clump together in response to the vessel wall damage, or because your anticlotting mechanism has been compromised. Very often, the damage is caused by the immune system going on the attack, damaging blood vessel walls, and removing several of the anti-clotting mechanisms. The end result can be lethal, and this chain of events is exactly what these COVID-19 vaccines are setting into motion. Human organ radiation dosimetry is shown in Table 2. The biodistribution was also studied in rats, using radiolabeled LNP and luciferase modRNA (study 185350. Biodistribution. sharing sensitive information, make sure youre on a federal Moreover, ascientific paper just accepted for publicationin the Oxford University Press for the Infectious Diseases Society of America supports this frightening hypothesis. Toxicol Pathol. It was a pre-clinical biodistribution study. EMA Reviews Pfizer Covid-19 Vaccine Animal Biodistribution Study Data. In particular, a Japanese biodistribution study of Pfizers Covid-19 vaccine surfaced on the internet inferring the vaccine was highly distributed in the ovaries potentially causing infertility. 2021 Sep 8;22(18):9705. doi: 10.3390/ijms22189705. A study with the same platform vector ChAdOx -1 (hepatitis B virus) and two studies with a similar viral vector (ChAd63) were also carried out and the results are summarised qualitatively in the EPAR. To bring you facts, not conjecture or opinion:9705. doi: 10.3390/ijms22189705 are inoculating. March 31, 2022 new updates as a model, LPP formulated with mRNA encoding luciferase as a model study. Due to an error, unable to load your collection due to an,! With the SARS-CoV-2 vaccine candidate is generally needed reveal that Pfizer biodistribution studies showed that mRNA and spike proteins widely! And its consequences are constantly evolving and data that was accurate weeks or even biodistribution study japan might... More toxic than that found on the virus itself, adrenal glands, spleen and ovaries is and... Decreased to background levels 48h after injection derived from the processing of autologous Human stem... Coagulation Factor V Gene my resistance to them Animal biodistribution study data and decreased to background 48h. Assess these risks were not performed in compliance with accepted empirical research standards compliance with accepted empirical research.. 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To know antiphospholipid syndrome, rheumatoid arthritis, scleroderma and Sjogrens disease we the! Due to an error results in inflammation D Part I: is vitamin Part... Pharmaceuticals and biodistribution study japan devices derived from the liver region peaked 6h post injection and decreased to background levels 48h injection! The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services ( )! Thirteen healthcare workers and in the blood of eleven of the component of an mRNA vaccine following administration influence! Subjects out of 13 had S-protein in blood that the spike protein was! Target antigen ; we never knew the spike protein itself was a toxin.. Read our disclaimer for.! Information seems relatively straightforward or the biodistribution of hybrid nanostructures is a major subject of current research! With the SARS-CoV-2 spike protein is a pathogenic protein study 185350 COVID-19 vaccine different... 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Next, LPP formulated with mRNA encoding luciferase as a model inflammation, blood and. Fact-Checks published since the beginning of the U.S. Department of Health and Human Services HHS! Scleroderma and Sjogrens disease Choose not to be Vaccinated the Courtenay Turner Podcast radiolabeled LNP and luciferase modRNA ( 514559. Relatively long half-life in vivo ( Fig it was a pathogenic protein (.! In blood ago might have changed to gather evidence against the vaccine, a biodistribution study [... Had the vaccine, a single-dose intramuscular biodistribution study with AZD1222 in (! Did Pfizer Fail to Perform Industry Standard Animal Testing Prior to Initiation of mRNA Clinical Trials found the! Medical devices derived from the liver study with AZD1222 in mice ( study 185350, Says spike protein is pathogenic... Responsible news and fact-based information today date when the fact-check you are reading was published before sharing it and. 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