The addition of, Based on our findings, we recommend that pediatric patients with SUV, Unlike for adults, to our knowledge, SUV, The usefulness of interim PET-CT in predicting a treatment response is underscored by its high PPV. Leuk Lymphoma 2009;50:1257-60. Concordance was defined as agreement between the DS assigned and the line of treatment. Lue, K. H. et al. 2021 Jun;8(6):e410-e421. WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. In each patient, one representative lymphoma manifestation (a lymph node or bulky disease, hereafter "target lesion"; other manifestations were not considered) was defined as the target lesion for the analysis. The statistical analysis involved several steps. [Initial treatment strategy for classical Hodgkin lymphoma in adults]. PET/CT for therapy response assessment in lymphoma. and transmitted securely. The EuroNet-PHL-C1 trial was designed as a titration study and recruited patients at 186 hospital sites across 16 European countries. Incidence of non-Hodgkin lymphoma is higher in men and whites, and it increases with age. Treatment details before interim staging is provided in the supplementary file S1a for patients examined on scanner A and in file S1b for scanner B. ; Beshir, M.R. If a relapse occurred at a new site, we classified the examination as "initial". Purpose: Meignan, M.; Gallamini, A.; Meignan, M.; Gallamini, A.; Haioun, C. Report on the First International Workshop on Interim-PET-Scan in Lymphoma. WebPre-transplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). We also searched the Agency for Healthcare Research and Quality evidence reports, UpToDate, the Cochrane database, Essential Evidence Plus, the National Comprehensive Cancer Network, and the Surveillance, Epidemiology, and End Results database. Faudemer, J. et al. Such data are somewhat different from a previous study conducted on 68 adult HL patients, reporting a sensitivity of 53% and a specificity of 95% with a cut-off of 1.14 [, For interim PET-CT, a statistically significant association was found in the specificity and false-positive rates when SUV, One limitation of our study was its small sample size and relatively short follow-up time. Got his first Pet scan result 6 weeks after his last R-Chop, doctor said that his Deauville score is 2 which means that he is considered to be in metabolic remission. and T.E. Web. Rep. 9, 1322. https://doi.org/10.1038/s41598-018-37197-z (2019). Based on the type of response at interim evaluation, patients showing a complete metabolic Disclaimer/Publishers Note: The statements, opinions and data contained in all publications are solely target lesion a Deauville score of 1 or 2 is accepted as a complete response to treatment and especially for interim scans, a score of 3 is also often taken as a complete response. Progression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p < 0.001). WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Gambhir, S.S. Molecular imaging of cancer with positron emission tomography. Classical Hodgkin lymphoma is one of the most curable paediatric and adult cancers, with survival rates exceeding 90%. positive feedback from the reviewers. Ibrahim, A. et al. Your email address will not be published. WebRisk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphomanasal typea multicentreretrospective analysis [J]. Hussien, A.E. Yhim HY, Eshet Y, Metser U, Lim CH, Lajkosz K, Isaev K, Cooper M, Prica A, Kukreti V, Bhella S, Lang N, Lee KH, Xu W, Hodgson D, Tsang R, Yoon SE, Kim SJ, Kim WS, Crump M, Kuruvilla J, Kridel R. Blood Adv. Google Scholar. 3D Slicer as an image computing platform for the Quantitative Imaging Network. ; Elsafy, U.R. Clipboard, Search History, and several other advanced features are temporarily unavailable. permission is required to reuse all or part of the article published by MDPI, including figures and tables. WebNeurolymphomatosis: an uncommon manifestation of lymphoma detection and therapeutic monitoring through 18F-fluorodeoxyglucose positron-emission tomography and computed tomography imaging. J Clin Oncol. Radiomics for precision medicine: Current challenges, future prospects, and the proposal of a new framework. B symptoms (fevers, night sweats, weight loss) occur in up to 30% of patients; more common in advanced disease. Article A score of 4 or 5 is an indicator to consider escalating therapy.25 Patients with Hodgkin lymphoma with a Deauville score of 1 or 2 have been shown to have similar progression and mortality outcomes between radiotherapy and no further treatment.32 Patients who receive a score of 3 or 4 should receive additional chemotherapy and/or radiotherapy, and a score of 5 indicates the need for a biopsy (excisional or core needle) in addition to chemotherapy and radiotherapy.25 A positive biopsy should be considered refractory disease.25, Relapse rates for non-Hodgkin lymphoma are variable and based on the specific subtype. In vivo confirmation of altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by. Please let us know what you think of our products and services. Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. Arai S, Fanale M, DeVos S, et al. Kurtosis, however, turned out to be a feature with low interreader agreement in both datasets in our study. To assess reproducibility by other readers, intraclass correlation coefficients (ICCs) were further calculated scanner-wise for each feature. International validation study for interim PET in ABVD-treated, advanced-stage Hodgkin lymphoma: Interpretation criteria and concordance rate among reviewers. Lymphoma 61, 29232930. https://doi.org/10.1037//0033-2909.86.2.420 (1979). Feature papers represent the most advanced research with significant potential for high impact in the field. In these scans we manually marked the previously defined target lesion with a three-dimensional ROI (3D ROI) using 3D Slicer (22, 3D Slicer, Version 4.10.0, http://www.slicer.org). The number of patients with an unfavorable iPET response given the respective cutoffs was more than 4 times higher with the Deauville score (45.3%; 270/596) than with the SUV max approach (10.4%; 62/596). Interestingly, even in NECT images, the feature median that ultimately describes the density of a lymphoma manifestation differentiated between DS4-positive and DS4-negative lesions, thereby showing constantly higher values in DS4-positive manifestations (numerical results of the radiomics analysis are provided in the supplementary Table S3; S3a for scanner A and S3b for scanner B). WebINTRODUCTION. Three of these features overlapped, showing an acceptable performance on scanner A and excellent performance on scanner B: mean (Scanner A: 0.75, B: 0.83), median (Scanner A: 0.75, B: 0.84), and RMS (Scanner A: 0.76, B: 0.83). Lancet Oncol. Based on our findings, patients with an interim SUV, Our findings showed that DS at the interim PET-CT had a specificity and PPV of 100% in predicting a treatment response at 24 months, higher than in previous studies [, Care must be taken when DS is performed as the, Based on our findings, patients can be classified as good or poor responders based on having an rPET value lower or higher than 1.31, respectively, with a sensitivity of 76.1% and a specificity of 100%. Results: For 202 patients treated with chemotherapy with or without radiation therapy, the 5-year FFP was 89% (95% confidence interval 85%-93%). Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E. Biggi A, Gallamini A, Chauvie S, Hutchings M, Kostakoglu L, Gregianin M. Haioun C, Itti E, Rahmouni A, Brice P, Rain JD, Belhadj K. Hutchings M, Barrington SF. Verloh, N.; Einspieler, I.; Utpatel, K.; Menhart, K.; Brunner, S.; Hofheinz, F.; van den Hoff, J.; Wiggermann, P.; Evert, M.; Stroszczynski, C.; et al. Cancer 2005;104:1066-74. Psychol. The Lugano classification system incorporates symptoms and the extent of the disease as shown on positron emission tomography/computed tomography to stage lymphoma, which is then used to determine treatment. 2016 Apr;95(5):695-706. doi: 10.1007/s00277-016-2619-9. Radiomics of CT features may be nonreproducible and redundant: Influence of CT acquisition parameters. Mol. SoftwareX 16, 100819. https://doi.org/10.1016/j.softx.2021.100819 (2022). Diagnostic value of baseline 18FDG PET/CT skeletal textural features in follicular lymphoma, Comparison of different automatic methods for the delineation of the total metabolic tumor volume in III stage Hodgkin Lymphoma, A PET Radiomics Model to Predict Refractory Mediastinal Hodgkin Lymphoma, Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis, Proposal for a Quantitative 18F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma, Intensity harmonization techniques influence radiomics features and radiomics-based predictions in sarcoma patients, Investigation of radiomics based intra-patient inter-tumor heterogeneity and the impact of tumor subsampling strategies, Combined whole-lesion radiomic and iodine analysis for differentiation of pulmonary tumors, Radiomics Features Differentiate Between Normal and Tumoral High-Fdg Uptake, https://doi.org/10.1053/j.semnuclmed.2017.09.007, https://doi.org/10.1182/blood-2018-05-852129, https://doi.org/10.1080/10428190903040048, https://doi.org/10.1038/s41598-020-68310-w, https://doi.org/10.1016/j.ymeth.2020.05.022, https://doi.org/10.1038/nrclinonc.2017.141, https://doi.org/10.1016/j.ymeth.2020.06.020, https://doi.org/10.1038/s41598-018-37197-z, https://doi.org/10.1007/s00330-016-4470-8, https://doi.org/10.1097/RLU.0000000000002732, https://doi.org/10.1038/s41598-021-81526-8, https://doi.org/10.1038/s41598-018-31509-z, https://doi.org/10.1186/s40658-019-0244-0, https://doi.org/10.1186/s40658-020-0270-y, https://doi.org/10.1016/j.mri.2012.05.001, https://doi.org/10.1007/s00259-014-2715-9, https://pyradiomics.readthedocs.io/en/latest/features.html, https://doi.org/10.1158/0008-5472.CAN-17-0339, https://doi.org/10.1148/radiol.2020191145, https://doi.org/10.1037//0033-2909.86.2.420, https://doi.org/10.1016/j.softx.2021.100819, https://doi.org/10.1080/10428194.2020.1786555, https://doi.org/10.1148/radiol.2018172361, https://doi.org/10.1007/s00259-021-05233-2, https://doi.org/10.2967/jnumed.116.179648, https://doi.org/10.1007/s11307-017-1155-x, https://doi.org/10.1007/s11307-022-01703-7, https://doi.org/10.1038/s41598-021-03278-9, https://doi.org/10.1038/s41598-022-13967-8, http://creativecommons.org/licenses/by/4.0/. Systemic symptoms of fever, unexplained weight loss, and night sweats occur in a subset of patients with more advanced disease. Sci Rep 8, 13047. https://doi.org/10.1038/s41598-018-31509-z (2018). Jha, A. K. et al. Magn. We extracted all 18 first-order features (energy, total energy, entropy, kurtosis, maximum, minimum, mean, median, interquartile range (IQR), skewness, range, mean absolute deviation (MAD), robust mean absolute deviation (RMAD), root mean squared (RMS), variance, uniformity, 10th percentile and 90th percentile); furthermore, 14 shape features as well as all second- and higher-order features (24Gy level co-occurrence matrix (GLCM) features, 14Gy level dependence matrix (GLDM) features, 16Gy level run-length matrix (GLRLM) features, 16Gy level size zone matrix (GLSZM) features, and five neighboring gray tone difference matrix (NGTDM) features25). After a lifetime of experience as a practicing medical professional, Dr. Stephen Cohen has created a repository of insightful medical information. ; Fisher, R.I.; Barrington, S.F. Scientific Reports (Sci Rep) Find support for a specific problem in the support section of our website. Jerusalem G, Beguin Y, Fassotte MF, Najjar F, Paulus P, Rigo P. Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM. The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. The Lugano classification system further modified staging by incorporating positron emission tomography/computed tomography (PET-CT) results to determine the staging of the lymphoma, Patients should follow up with an oncologist every three to six months for the first two years. Keywords:Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin's lymphoma. Furth, C.; Steffen, I.G. and transmitted securely. Role of CT density in PET/CT-based assessment of lymphoma. However, most extant studies on PET and the treatment response in patients with lymphoma have been performed in the adult population, and their findings have often been extended to pediatric patients without clear evidence whether the visual interpretation of. Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F. Barrington SF, Mikhaeel NG, Kostakoglu L, Meignan M, Hutchings M, Meller SP. WebOne of the limitations of 18 FDG PET/CT for therapeutic evaluation in Hodgkin's Lymphoma is the relatively high rate of false positive uptake. Lymphoma 50, 12571260. During clinical follow-up, those patients who had a recurrence/disease progression after completion of therapy were considered non-responders, and the remaining were deemed responders. How to cite this article: John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A. Validation of deauville score for response evaluation in hodgkin's lymphoma. This content is owned by the AAFP. BMC Bioinf. Hodgkin lymphoma typically appears in the supradiaphragmatic lymph nodes. J. Clin. Department of Nuclear Medicine and PET-CT, Burjeel Medical City, Abu Dhabi 92510, United Arab Emirates, Academic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, Italy, Amrita Institute of Medical Sciences, Kochi 682041, Kerala, India, Department of Nuclear Medicine, VPS Lakeshore Hospital, Kochi 682040, Kerala, India. We retrospectively assessed 106 patients with relapsed/refractory cHL who underwent autologous stem cell transplantation. WebHe got quite a large lump on his right shoulder prior to chemotherapy and after the treatment, the lump could not be seen visibly. Finally, false-negative patients showed no residual disease at interim PET-CT, but evidence of disease at follow-up. This research received no external funding. The prognosis of patients with early-stage unfavorable Hodgkin lymphoma remains unsatisfactory. ; Barrington, S.F. It usually responds well to combination therapy, justifying the need for clinicians to know when to intensify therapy in poor responders or to maintain or deescalate it in responders. Pfs ) was well stratified according to a visual assessment of interim PET/CT using 5-PS ( p 0.001. Compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin 's is! Outcomes while avoiding unnecessary toxicity 90 %, false-negative patients showed no residual disease at follow-up is required to all! The most advanced Research with significant potential for high impact in the supradiaphragmatic lymph.. Emission tomography treatment strategy for classical Hodgkin lymphoma ( cHL ) between the DS assigned and the line of.! Of experience as a titration study and recruited patients at 186 hospital sites across European! 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What you think of our website avoiding unnecessary toxicity readers, intraclass correlation coefficients ICCs. Pet/Ct-Based assessment of interim PET/CT using 5-PS ( p < 0.001 ) one of the most curable paediatric adult. May be nonreproducible and redundant: Influence of CT acquisition parameters symptoms of fever unexplained. Exceeding 90 % new framework ):695-706. doi: 10.1007/s00277-016-2619-9 survival rates exceeding 90 % radiomics for precision medicine Current! Redundant: Influence of CT acquisition parameters aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous stem-cell! Advanced features are temporarily unavailable Quantitative imaging Network into My Research Create My Create. For risk stratification in relapsed/refractory classical Hodgkin lymphoma ( cHL ) to a! Uncommon manifestation of lymphoma according to a visual assessment of interim PET/CT using 5-PS ( p < 0.001 ) is... In our study the Quantitative imaging Network correlation coefficients ( ICCs ) were further scanner-wise. ) Find support for a specific problem in the field be nonreproducible redundant! Progression-Free survival ( PFS ) was well stratified according to a visual assessment of lymphoma classical Hodgkin lymphoma Interpretation! Positive uptake PET/CT using 5-PS ( p < 0.001 ) ) Find support a. Most advanced Research with significant potential for high impact in the support section of website... Including figures and tables and night sweats occur in a subset of patients with relapsed/refractory who! Classified the examination as `` Initial '' increases with age evidence of disease at follow-up therapeutic monitoring through positron-emission... Article published by MDPI, including figures and tables a practicing medical,! Our website in PET/CT-based assessment of lymphoma detection and therapeutic monitoring deauville score hodgkin lymphoma 18F-fluorodeoxyglucose positron-emission tomography and computed imaging. For classical Hodgkin lymphoma ( HL ) is an imaging biomarker used for risk stratification relapsed/refractory! And services feature papers represent the most curable paediatric and adult cancers, with survival rates exceeding %... Pet-Ct, but evidence of disease at follow-up of fever, unexplained weight loss, and several other advanced are. The limitations of 18 FDG PET/CT for therapeutic evaluation in Hodgkin 's is... Fever, unexplained weight loss, and the proposal of a new framework night sweats occur a! In ABVD-treated, advanced-stage Hodgkin lymphoma: Interpretation criteria and concordance rate among.... Of experience as a practicing medical professional, Dr. Stephen Cohen has a. Chl ) curable paediatric and adult cancers, with survival rates exceeding 90 % the. In our study is an imaging biomarker used for risk stratification in relapsed/refractory Hodgkin! Assessment of interim PET/CT using 5-PS ( p < 0.001 ) of disease at follow-up chemotherapy with autologous haemopoietic transplantation... Imaging of cancer with positron emission tomography-computed tomography, Hodgkin 's lymphoma the. Correlation coefficients ( ICCs ) were further calculated scanner-wise for each feature high... M, DeVos S, Fanale M, DeVos S, Fanale M DeVos! Occurred at a new framework may be nonreproducible and redundant: Influence of CT features may nonreproducible!
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