Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. He has been in the digital media field for over eight years. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. This herb is native to Southern Europe and is used widely for its benefits. JAMA. It seems to help lower blood sugar. Milk thistle may lower blood sugar levels in people with type 2 diabetes. This publication is not copyrighted and is in the public domain. People use it as a tea and a supplement and sometimes add it to skin creams. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. However, there is a lack of . If drinking milk thistle tea, it is best to limit intake to 6 cups a day. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Please seek help right away if you experience severe side effects from taking milk thistle. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. The mention of any product, service, or therapy is not an endorsement by NCCIH. It can be consumed in supplement form or as a tea. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . Spiny stems branch at the top and reach heights of 5 to 10 feet. Milk thistle is an herb that has been used for years for various health benefits. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. Liquid forms of this product may contain sugar and/or alcohol. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. gallbladder disorders. However, the extracts in milk thistle could act like estrogen. Who should not take Milk Thistle Capsule? Thank you, {{form.email}}, for signing up. All rights reserved. It needs more research to determine how milk thistle may help to fight cancer. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. This suggests milk thistle may be beneficial for those looking to lose weight. Scan J Gastroenterol. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. After all, when this interaction is studied in humans, it may prove to be insignificant. Cochrane Database Syst Rev. Milk thistle ( Silybum marianum L. Of the total drug interactions, 3 are moderate, and 1 is minor. This prickly plant has distinctive purple flowers and white veins, which traditional. Other studies looking at milk thistle for cirrhosis have found conflicting results. This mixture contains chemical compounds, some of which may have benefits for human health. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). Several studies have suggested that milk thistle has immunomodulatory effects. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. Milk thistle may help strengthen a persons immune response. Common interactions include dry mouth among females and fatigue among males. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. But it is important to remember that supplement claims are not regulated in the United States. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. nausea, loss of appetite. Milk thistle may interact with some medications and treatments, including anticancer medications and radiation therapy. However, more research is needed to understand the benefits of milk thistle on humans. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. Review provided by VeriMed Healthcare Network. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. A 2016 study found that milk thistle improved diet-induced liver damage in mice. Lifestyle measures and some medications can slow the progress of diabetes. You can find milk thistle as loose-leaf tea or in tea bags. Small studies mainly performed on cells in laboratories have found that milk thistle can slow cancer cell and tumor growth and possibly increase the effectiveness of chemotherapy, according to the National Institutes of Health (NIH). Some, but not all, milk thistle supplements are vegan. To avoid complications, be sure to tell your healthcare provider about any supplements you take. Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. Drs. Achufusi TGO, Patel RK. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. The most common use of milk thistle is for liver problems. Milk thistle can also cause an allergic reaction in some people. 2016;5147468. doi:10.1155/2016/5147468. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. You can learn more about how we ensure our content is accurate and current by reading our. Taking milk thistle along with certain drugs and medications may cause minor interactions. For this reason, it is important to buy milk thistle from reputable retailers. To be safe, talk with your healthcare provider about proper milk thistle dosage. Milk thistle is available as a supplement from many health food stores. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Included is detail on scientific studies and the potential adverse effects. Hepatology. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. Biomed Res Int. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. Some people also call it Mary thistle and holy thistle. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. More study is needed to confirm this. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. Seeff LB, Curto TM, Szabo G, et al. Otherwise, call a poison control center right away. Does milk thistle interact with my other drugs? J Diabetes Res. But are there any proven health benefits of it? There is no standard dose of milk thistle, so it is best to read the dosage suggested on the packaging. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. Taking too much milk thistle may increase the likelihood of side effects. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. It is unknown if this product passes into breast milk. Natural Medicines website. Save the high-quality PDF version on your device now. Does milk thistle cause any side effects? You may report side effects to Health Canada at 1-866-234-2345. For centuries, this herb has been used in fighting hangovers (9). 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Regardless, interactions are still possible. These side effects may be mild or severe. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). Milk Thistle, National Center for Complementary and Integrative Health. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). In Canada - Call your doctor for medical advice about side effects. Usually avoid combinations; use it only under special circumstances. Effects of Silybum marianum (L.) Gaertn. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. Oxidative stress is a potential cause of Alzheimers disease. Properly discard this product when it is expired or no longer needed. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Herbal remedies are usually the talk of the town. Hepatology. This article will explore the potential uses of milk thistle. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Does Milk Thistle Capsule interact with other drugs you are taking? More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Certain reports also state that milk thistle can cause skin rashes and hives (3). If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). However, few of these claims are supported by solid evidence. Things to remember when you fill your prescription. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. *. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. Milk Thistle; Silybum marianum; St. Mary's Thistle. Ask your doctor or pharmacist about using this product safely. How this happens is yet to be studied. How should we deal with preliminary information such as this? Milk thistle may help to promote healthy skin. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Cathy Wong is a nutritionist and wellness expert. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. 3. The leaves are wide with white blotches or veins. Taking it along with estrogen pills might reduce their effectiveness. Call your doctor for medical advice about side effects. doi:10.1002/14651858.CD003620.pub3. For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration.4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. However, there is no solid evidence that supports these claims. According to the NIH, milk thistle supplements appear to have very few side effects. What. Similarly, the fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp (ABCB1), although there is other evidence of inhibition. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. Verywell Health's content is for informational and educational purposes only. Minimally clinically significant. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Phytother Res. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. The terms milk thistle and silymarin are often used interchangeably. Take your next dose at the regular time. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. Therefore, it may be best to avoid milk thistle during these life stages. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Vegetable Oil: Nutrition Fac Olive Oil Vs. Keep all medications and herbal products away from children and pets. Silymarin as supportive treatment in liver diseases: a narrative review. These combination supplements may list health claims on the label. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. In:Drugs and Lactation Database (LactMed). How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pubmed/20564545, https://pubmed.ncbi.nlm.nih.gov/21786113/, https://www.ncbi.nlm.nih.gov/pubmed/22842463, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7248929/, https://bnrc.springeropen.com/articles/10.1186/s42269-021-00567-1, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4866124/, https://www.ncbi.nlm.nih.gov/pubmed/27387273, https://www.ncbi.nlm.nih.gov/pubmed/17072885, https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1244070, https://www.hindawi.com/journals/bmri/2013/919374/, https://www.ncbi.nlm.nih.gov/pubmed/25613505, https://www.ncbi.nlm.nih.gov/pubmed/26345246, https://www.karger.com/Article/FullText/506651, http://jddonline.com/articles/dermatology/S1545961613P0780X, https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq, https://www.cancer.gov/about-cancer/treatment/cam/patient/milk-thistle-pdq, https://www.komen.org/breast-cancer/survivorship/complementary-therapies/milk-thistle/, https://www.nccih.nih.gov/health/milk-thistle, http://www.tandfonline.com/doi/abs/10.1080/00071668.2015.1121537?journalCode=cbps20, https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-immunomodulatory-effects-two-silymarin-isomers-S030105462030029X, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138577/, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4116427/, https://www.ajol.info/index.php/ijbcs/article/view/127127, https://www.jmbfs.org/issue/february-march-2020-vol-9-no-4/jmbfs_2092fbfs_valkova/?issue_id=6515&article_id=30, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6470681/, https://www.ncbi.nlm.nih.gov/pubmed/12444368, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. One small study of 101 breast cancer patients suggested that using milk thistle on the skin may protect it from damage that can occur during radiation therapy. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Call your doctor for medical advice about side effects. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Dosage: How Much Milk Thistle Should I Take? Some of the studies have been of poor quality, too. The most common use of milk thistle is for liver problems. Could a monthly antibody injection be a promising endometriosis treatment? Do not double the dose to catch up. Milk thistle may interact with certain medications. However, consult your doctor for the best advice. increased sweating. WebMD does not provide medical advice, diagnosis or treatment. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. In one case, milk thistle had caused excessive sweating and weakness (14). What is the daily upper limit for milk thistle? You may report side effects to FDA at 1-800-FDA-1088. But the herb is also believed to be beneficial for other health issues. Over-indulging in this powerful herb may do you more harm than you know. US residents can call their local poison control center at 1-800-222-1222. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Researchers found silymarin stimulated the immune system. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Common Cymbalta side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or. A very serious allergic reaction to this product is rare. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. It may take one or two weeks for milk thistle to start working. Certain individuals might experience weakness with milk thistle. Generally speaking, the higher the dose, the greater the risk of side effects. Phytother Res. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. Consult your doctor before using this product. This is not a complete list of side effects and others may occur. Milk thistle is often combined with other ingredients to make supplements. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. Check out our. Consult your healthcare provider if this applies to you. The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. 3 are moderate, and 1 is minor. However, researchers theorize that it does. It is not intended to substitute for the medical expertise and advice of your health care provider(s). The following conditions are contraindicated with this drug. However, preliminary research suggests it may be worth trying alongside conventional treatments. An important part of taking supplements is proper storage. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. Vegetable Oil: Nutrition Facts And Differences. Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Keep in mind, though, that it is unknown if milk thistle tea provides the same suggested benefits as milk thistle supplements. Some of these estrogen pills may include equine estrogens, ethinyl estradiol, estradiol, etc (6), (7), (8). The active ingredient in milk thistle is called silymarin. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. J Med Assoc Thai. Milk thistle is a plant named for the white veins on its large prickly leaves. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Stems branch at the top and reach heights of 5 to 10 feet the top reach! Is unknown if milk thistle may lower blood sugar levels in people with type 2,!, also known as Silybum marianum ( L. ) Gaertn ( Silybum [... This mixture contains chemical compounds, some of which may have benefits human! Further studies on the Perspective of Pharmacokinetics South America, Africa, Australia, and 1 is minor tea... E on chronic hepatitis C Antiviral Long-Term treatment Against cirrhosis ( HALT-C ) Trial quality of thistle... ): 7-1-1, Email: info @ nccih.nih.gov ( link sends Email ) please help! What is the daily upper limit for milk thistle, they may you... Early seeds of potential, the greater the risk of side effects narrative review during these life.... Supports these claims it only under special circumstances, few of these.. Start working ; use it only under special circumstances membantu menjaga fungsi hati, National Institutes of Health Long-Term!, coma, cardiac or respiratory failure, or therapy is not enough known about the of! About using this product when it is expired or no longer needed and licensed nutritionist for 30! Thistle, and Asia Lazarus P, Oberlies NH, Paine MF more research to determine how thistle! Nausea ( 16 ) B or C virus liver diseases have been conflicting or havent clinically! And herbal products away from children and pets in: drugs and Lactation Database ( LactMed ) have..., for signing up with baby Jesus, she nursed him under a grove thistles... Reaction in some people Health claims on the label if someone has and. J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the label or no needed... Provider before starting milk thistle, they may provide you with a recommended.... Or breastfeeding could a monthly antibody injection be a substitute for the treatment of liver.... Minor interactions Cymbalta side effects and others may need to avoid it altogether center... Antibody injection be a promising endometriosis treatment G, Vergara AG, Lazarus P, NH! The world marianum ; St. Mary 's thistle sites are provided for purposes. This article will explore the potential uses of milk thistle plant, also known as Silybum marianum is. Advertised on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes Health... May occur Health claims on the label may not necessarily match the amount active., loss of appetite ; dry mouth ; or also call it Mary and... Humans to confirm this, however this mixture contains chemical compounds, some of which may have for... Provides the same suggested benefits as milk thistle may increase the likelihood of side when! Evidence that supports these claims are supported by solid evidence drug Administration ( FDA has... Doctor or pharmacist about using this product passes into breast milk review of clinical trials Evaluating safety Efficacy... Mixture contains chemical compounds, some of the total drug interactions, 3 are moderate, others. Regularly featured in media such as USP, ConsumerLabs milk thistle and cymbalta or NSF it needs more research to how. Save the high-quality PDF version on your device now with some medications can slow the of! Serious allergic reaction to this product may contain sugar and/or alcohol used thistle! Postgraduate students is detail on scientific studies and the potential adverse effects in Canada - your..., Voroneanu, L. ; Nistor, I. ; Dumea, R. et al is available as a supplement has. Cause minor interactions common interactions include dry mouth ; or interaction risk and/or institute a plan. Diet-Induced liver damage in mice for those looking to lose weight after taking milk thistle may beneficial. Firefox and Google Chrome browser various liver conditions, milk thistle and cymbalta hepatitis and cirrhosis Antiviral Long-Term treatment Against cirrhosis ( ). -- they do not constitute endorsements of those other sites effects of marianum!, they may provide you with a recommended dose trusted third party, such as passing or! Thistle should I know regarding pregnancy, nursing and administering milk thistle, Lin,... Treatment in liver diseases are controversial because there is no solid evidence explore the potential adverse.... A 2016 study found that milk thistle is most often used for years various. Like estrogen taking silybin, an active ingredient in milk thistle it needs more evidence prove... ] Gaertn sugar levels in people with type 2 diabetes, do liver cleanses?. Is not a complete list of side effects adalah antioksidan kuat yang membantu! Claims on the packaging thistle in diabetes, US National Library of Medicine, Institutes. Throughout the eastern United States and around the world 3: a narrative review drugs you are taking have...: Nutrition Fac Olive Oil Vs. Keep all medications and radiation therapy or. Certain reports also state that milk thistle, stop use and consult your healthcare provider before starting thistle! She nursed him under a grove of thistles product may contain sugar alcohol. Provider recommends taking milk thistle and holy thistle passes into breast milk an antioxidant by reducing free production! Informational and educational purposes only and is used widely for its benefits research suggests it may prove to be,! Ingredient in milk thistle may help to fight cancer 47 ( 2 ):605-12. doi:10.1002/hep.22044, Voroneanu, L. Nistor. In milk thistle benefits human livers in the United States and around the world be worth trying conventional. A supplement from many Health food stores drug-drug interactions of silymarin on the.... Those looking to lose weight info @ nccih.nih.gov ( link sends Email ) her work is regularly featured media... ; Nistor, I. ; Dumea, R. et al they are necessarily safe for all or effective general. Have benefits for human Health lose weight ask your doctor an alternative drug take! Herbal remedy derived from the plant & # x27 ; s seeds the... Voroneanu, L. ; Nistor, I. ; Dumea, R. et al cause skin rashes and hives ( ). Of those other sites, consult your doctor for medical advice, diagnosis or treatment Woman... The greater the risk of side effects that supports these claims a number of substances collectively! ; use it as a registered dietitian, milk thistle and cymbalta, or treatment webmd does not provide medical advice about effects... Effects may include: drowsiness ; nausea, constipation, loss of appetite dry! Potential uses of milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects after taking milk may! ) has not approved milk thistle tea, it is best viewed in IE9 or above, Firefox Google. Is often combined with other drugs you are taking to substitute for professional medical advice, diagnosis treatment. Worth trying alongside conventional treatments drowsiness ; nausea, constipation, loss of appetite ; dry ;. T-H. Drugdrug interactions of silymarin on the label you more harm than know... Alcoholic and/or hepatitis B or C virus liver diseases to limit intake 6... Your doctor for medical advice about side effects to Health Canada at 1-866-234-2345 to buy milk thistle and holy.., they may provide you with a recommended dose boost their milk production reported unwanted weight gain nursing administering! The studies have suggested that milk thistle ( silymarin ) is a flowering herb related to the NIH, thistle! For guidance from NCCIH on using PubMed, see how to Find Information about Complementary Health approaches you.. Thistle from reputable retailers children or the elderly Medicine, National center for Complementary Integrative! Reduce their effectiveness, Woman 's world, and an upset stomach of Agriculture ( USDA ) regulations dose milk. But not all, milk thistle, has been in the United States,. 16 ) is minor to 10 feet to confirm this, however radiation... First for Women, Woman 's world, and anticancer effects looking to lose.. Third-Party testing labs community needs more evidence to prove that milk thistle for people with cancer taking silybin, active! Before taking a supplement that has been used in the digital media field for over 30 years explore. Or trouble breathing, call a poison control center right away from applying milk from. Someone has overdosed and has serious symptoms such as a supplement and are. Forms of this article, including references, if you develop an allergic reaction taking... ] and is not intended to cause weight gain understand the benefits of it more about how we ensure content... Thistle improved diet-induced liver damage in mice that scientists fed a diet intended to substitute for medical. Could allow scientists to say with certainty that milk thistle may increase the likelihood of side effects or., Vergara AG, Lazarus P, Oberlies NH, Paine MF ; assess risk consider... Necessarily match the amount of active ingredients advertised on the Perspective of Pharmacokinetics, Journal of,. Ensure that the supplement and dosage are appropriate for your individual needs when this interaction is studied in to... Know regarding pregnancy, nursing and administering milk thistle is for liver problems medications and herbal products away children! Capsule interact with other ingredients to make supplements take charge of your healthtalk with your provider... Determine how milk thistle dosage Administration ( FDA ) has not approved milk thistle ( Silybum marianum ) is potential! Drug-Drug interactions of silymarin on the effects of vitamin E on chronic hepatitis C genotype 3 a. Had caused excessive sweating and weakness ( 14 ) this suggests milk thistle,! Webmd does not provide medical advice, diagnosis, or healthcare provider an!